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KMID : 0948320030030010046
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Konyang Medical Journal
2003 Volume.3 No. 1 p.46 ~ p.57
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Effect of Treadmill Exercise on Neural Regeneration after Crush Injury of the Scientic Nerve in the Rats
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Bok Su-Kyung
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Abstract
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Objectives: After the crush injury to the unilateral sciatic nerve of the 60 male Sprague-Dawley ratsm the effect of exercise training on the functional recovery was evaluated after the forced exercise on the treadmill.
Method: The treadmill exercise group was divided into 4 subgroups(10 in each subgroup) according to the amount of work load and the starting time of the exercise(early of delayed). Exercise training was given for 25 minutes daily for 3 to 5 weeks. Functional recovery was evaluated by the maximal angles on the inclined board that the rat could maintain its initial position, sciatic function index(SFI) calculated from the measurements of the foot prints, the latencies and amplitudes of the compound muscle action potentials(CMAP) recorded at gastrocnemius(GCM) after sciatic stimulation and the histological findings of the muscle action potentials(CMAP) recorded at gastrocnemius(GCM) after sciatic stimulation and the histological findings of the muscles of the leg. Statistical analysis was performed by ANOVA and post hoc grouping by Scheffe.
Result: 1) With the treadmill exercise, maximal angles on the inclined board, SFI, and the latencies and amplitudes of the CMAP recorded at GCM showed better recovery in the exercised group than the control group. 2) The evidence of nerve conduction across the injured segment was observed between the second and the third weeks after the injury in the exercised and comtrol group. 3) After treadmill exercise there was no significant differnce in the moter behavior aw measured by the maximal angles and SFI between the 2 subgroups divided according to the beginning time of the exercise after the injury. 4) In the subgroups which started exercise after 2 weeks postinjury, ones after the exercise with higher workload showed better recovery in the motor behavior than the ones with the lower workload, 5) After treadmill exercise ther was an increase in th proportion of typeⅡ fiber in gastrocnemius but no interval change of fiber in soleus.
Conclusion: The exercise training in the rats after the sciatic nerve injury helped to improve motor behavior of the rats. The effect was better when exercise was started during the reinnervation phase and when the exercise was done with more workload. And in can be postulated that exercise training in the patients with peripheral nerve injury could be an effective tool in the rehabilitation process in clinical setting.
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KEYWORD
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Treadmill exercise, Crushed injury, Sciatic neve, Reinnevation
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